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pentobarbital will lessen the extent or outcome of etravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital will decrease the extent or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a delicate CYP3A4 substrate. Coadministration